Up-to-Date Optimization of the 90Y-PET/CT Reconstruction Protocol for Volumetric Quantification in Trans-Arterial RadioEmbolization (TARE) Procedures in the Era of Theranostics

(1) Background: New generation of PET-CT scanners allows performing volumetric dosimetry based on 90Y-activity distribution. The aim this study was to perform an up-to-date evaluation the optimal 90Y-PET-CT reconstruction parameters for a Siemens Biograph mCT scanner. (2) Methods: A cylindrical uniform phantom (P1), IEC NEMA Body-phantom (P2) and Torso-phantom (P3) filled with 90Y were acquired. matrix size number Equivalent Iterations (E.I.) evaluated through Recovery Coefficient (RC) Variation (CoV). post-reconstruction Gaussian Filter (GF) assessed analysis Root Mean Square Error (RMSE) Full Width at Half Maximum (FWHM) in DVHs. (3) Results: For P1, RC values showed constant trends varying (slope m = 1.25 × 10−3) or E.I. −2.16 10−4). P2, CoV decreased increasing it grew P3, RMSE mean dose filter 1.51 10−2) while FWHM filter. smaller volumes, (from 34% 74%) use larger filters resulted underestimation 172 133 Gy). (4) Conclusions: PET/CT scanner are presented, combining old metrics new ones involving dosimetric approach.